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Eli Lilly's orforglipron and Pfizer's daily acting danuglipron represent the latest oral non-peptide GLP-1 agonists, striving for parity in efficacy with the injectables, with the advantage of being more readily manufactured

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In addition to their impact on appetite and consummatory behaviors [207, 208], several mechanisms have been proposed to mediate GLP-1RAs effects on alcohol intake, including interactions with reward-related pathways [209,210,211,212], stress [213,214,215], cognition and neuroprotection [216,217,218], pain and aversion [113, 219, 220], and inflammation [221,222,223]